In addition, we describe problems with two recent randomized trial reports published in JAMA which were presented in a way that misled readers. In this paper, we summarize several flaws in the three papers. Two of the papers were authored by Thomas Chalmers, an influential expert in clinical trials, and the third was authored by Paul Meier, a famous medical statistician. The rejection of the demonstrated benefits of vitamin C is largely explained by three papers published in 1975-two published in JAMA and one in the American Journal of Medicine-all of which have been standard citations in textbooks of medicine and nutrition and in nutritional recommendations. However, in mainstream medicine, the views on vitamin C and infections have been determined by eminence-based medicine rather than evidence-based medicine. Evidence has shown unambiguously that, in certain contexts, vitamin C is effective against the common cold.
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